• Chris Sanders as Stitch - the main protagonist of the film. He wears a blue shirt, green vest, and red pants.
  • Anika Noni Rose as Angel - Stitch's love interest and the primary protagonist of the film. She wears a yellow and white three-piece skirted suit with matching shoes. She works as the Secretary of the Sunnyside Company. Stitch had crush on her. She surprisely falls in love with Stitch. Her goal is to become the great singer and the famous idol.
  • Kelsey Grammer as Locko - the main deutergonist of the film. He is a streetwise, brokenhearted alien with thin Brookyn accent.
  • Bud Luckey as Knuckles - one of the protagonists in the film. He is Locko's brother with a grey, thick moustache and an old man's voice. Luckey voices the narrator of the film.
  • Christopher Plummer as Killerclaw, the main antagonist of the film. He is a cunning, brutal, cruel, selfish, trash-talking, vain, dark-hearted alien. He is a brother of Locko and Knuckles who tries to flirt with Angel, and despises Stitch.
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