Like Stitch, Slither is very destructive and mischievous. He is also a physical, obedient, ruthless, psychotic, cunning, intelligent, murderous, devious, nefarious, and extremely aggressive creature.
Slither is a blood red reptilian koala/dragon-like experiment with a strong resemblance to Stitch, maroon nose, claws and toes, a crocodile-like jaws and mouth, a snake-like tongue, large pointed ears, a massive reptilian tail, light red skin on his belly, chest, and around his eyes (left eye is black and right eye is yellow reptilian) and dark maroon markings on his back, tip of his tail and tips of his antennae, ears and back spikes.
Like Stitch, Slither is able to mutate into second form with four arms, two long antennae on top of his head, and three sharper spikes on his back and the back of his head. He also possesses all of Stitch's abilities of brain, strength, speed, invulnerability, and fighting skills, to lift objects up to 3,000 times his weight and not an ounce more, think faster than a supercomputer, have super sight and hearing, be bulletproof and fireproof, have several different visions, including night vision, color vision, and heat vision, cling to walls and walk on the ceilings, like a gecko, roll into a ball, hear in different hearing levels, have venomous spikes, and eat stone, metal and flesh. He also possesses other abilities such as flight, teleporting, invisibility, shapeshifting, telekinesis, laser vision, plasma cannon blast, plasma shot, plasma bolts and webs, ice breath, fire breath, sonic roar, electric shock, energy blast and electricity. Slither has the ability to generate a green, electric energy in his hands, and mouth, which can be used to electrified anything he touch.
- Slither's manner is similar to Ch'rell from Teenage Mutant Ninja Turtles 2003 series.
- It's possible that Slither's ability to roll into a buzzsaw in his mutated form.
- Slither is similar to King Candy from Wreck It Ralph that besides of both being accomplished racers, they also serve as "foils" for the heroes (showing what they would've become if they didn't change their ways - Turbo for Ralph, and Slither for Stitch).
- Slither also has several similarities to some of the villains from the Pixar movies.